Activation of branched chain amino acid catabolism protects against nephrotoxic acute kidney injury.

In the AKI models, BT2 treatment led to slightly less body weight loss compared with the AAI + DMSO group, but this difference did not reach statistical significance ( Fig. 1 B ).

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p-BCKDH-E1α was significantly reduced in uninjured mice treated with BT2, with a strong trend toward reduced p-BCKDH-E1α in injured kidneys (Supplemental Fig.

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Serum BCAA concentrations were significantly higher in AAI + DMSO-treated mice and showed a nonsignificant trend toward reduction in AAI + BT2-treated mice ( Fig. 3 A ).

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