Suppression of the T-dependent antibody response following oral exposure to selected polycyclic aromatic compounds in B6C3F1/N mice.

If a significant trend was detected at p ≤ 0.01, Williams’ test was used ( Williams, 1986 ); if the trend was not significant, Dunnett’s test was used ( Dunnett, 1955 ).

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The shift in T:B cell ratio in mice treated with pyrene corresponded with an increasing trend observed for the B cell population (absolute and relative) and a decreasing trend for T cells (relative) with the relative counts being significant for both populations in mice treated with ≥25 mg/kg bodyweight/day pyrene.

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There was a negative trend for relative kidney weight with a significant reduction in mice treated with 200 mg/kg bodyweight/day pyrene (CEBS Summary Table PA06).

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The shift in T:B cell ratio in mice treated with pyrene corresponded with an increasing trend observed for the B cell population (absolute and relative) and a decreasing trend for T cells (relative) with the relative counts being significant for both populations in mice treated with ≥25 mg/kg bodyweight/day pyrene.

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