Hepatic IR and IGF1R signaling govern distinct metabolic and carcinogenic processes upon PTEN deficiency in the liver.

Furthermore, in silico analyses of INSR and IGF1R expression in HCC biopsies (LIHC–TCGA patient cohort) showed a trend toward increased RNA expression of both receptors in the cancerous biopsies compared with noncancerous livers ( Fig. 5 A).

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In contrast, IGF1R mRNA expression gradually increased at all stages, although this increase did not reach statistical significance ( Fig. 5 B).

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