Regulatory T cells in the mouse hypothalamus control immune activation and ameliorate metabolic impairments in high-calorie environments.

Nat Commun · 2025 · PMC11926360 · PMID 40113758

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hedged sentences

0.0643

closest p · 1.3× alpha

0.0643

boldest claim

The sentences

a clear trendP = 0.0643so close (0.05 < p ≤ 0.1)

transfer of Tregs into the hypothalamus supported a clear trend towards improved glucose tolerance ( P = 0.0643, Fig. 9g ) accompanied by trends toward reduced inflammatory NFκB-related genes in the adipose tissue (Supplementary Fig. 9e ).

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showed a trendno p-value reported

Ccr7 and Cd226 expression showed a trend towards an increase upon exposure to HFHS diet, while Cxcr3 and Ifng expression were significantly increased and thus, confirmed the Th1 polarization of CD4 + T cells isolated from mouse brains upon hypercaloric challenge.

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