The Combination of PPARα Agonist GW7647 and Imeglimin Has Potent Effects on High-Glucose-Induced Cellular Biological Responses in Human Retinal Pigment Epithelium Cells.

Bioengineering (Basel) · 2025 · PMC11939608 · PMID 40150729

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did not reach statistical significanceno p-value reported

showed a trendno p-value reported

First, ARPE19 cells cultured under high-glucose (50 mM) conditions showed a trend of increased proton leak, which could reflect increased ROS, compared to those cultured under low-glucose (5.5 mM) condition, but the difference did not reach statistical significance.

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