Chemogenetics with PSAM<sup>4</sup>-GlyR decreases excitability and epileptiform activity in epileptic hippocampus.

No statistically significant differences were observed for the number of APs during Imin, the lowest current step for AP induction, although there was a clear trend of reduction (decrease by 50% [range 37.5–75]; p = 0.0625; Fig. 2F , green).

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Although administration of uPSEM 817 in vivo did not significantly alter electrographic seizures in a male mouse model of temporal lobe epilepsy, it did demonstrate a strong trend toward reducing the frequency of interictal epileptiform discharges.

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