Insulitis and aging: Immune cell dynamics in Langerhans islets.

While old islets showed a trend toward secreting more insulin under high glucose conditions (p = 0.0550) and KCl stimulation (p < 0.001) ( Fig. 1 I), the variability in insulin secretion suggests that aging leads to more heterogeneous β-cell functionality. 3.2 Insulitis, immune cell accumulation of Langerhans islets, increases with age Inflammation and infiltrating immune cells can contribute to the loss of β-cells and affect their function.

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Protein carbonyls, indicative of oxidative damage to proteins, showed a significant increase in isolated islets from old mice, while 3-nitrotyrosine levels, a marker of nitrosative stress, showed a trend toward an increase, but did not reach statistical significance ( Fig. 6 D).

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