Disease-modifying pharmacological treatments of type 1 diabetes: Molecular mechanisms, target checkpoints, and possible combinatorial treatments.

A meta-analysis on DPP-4i used as intervention therapy in 253 diagnosed T1D patients pooled from 5 randomized controlled trials showed a trend to decrease in HbA1c levels and improvement in insulin demands and glycemic control ( Wang et al, 2018 ).

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In the meantime, the observed HbA1c decrease in all treatment arms did not reach statistical significance, and the combination treatment was well tolerated, with the majority of adverse events associated with gastrointestinal disorders, a known effect of GLP-1RA.

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