Memory Boost for Recurring Emotional Events Is Driven by Initial Amygdala Response Promoting Stable Neocortical Patterns across Repetitions.

J Neurosci · 2025 · PMC11968526 · PMID 39947923

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approached significanceno p-value reported

No interaction involving the factor memory approached significance in both the right (all | β | < 1.654; all p corr > 0.130) and left PHC (all | β | < 0.449; all p corr > 0.653).

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failed to reach statistical significanceno p-value reported

The right perirhinal cortex (PRC) showed a similar trend to the anterior MTL, with a higher involvement for successfully remembered emotionally negative compared with neutral items at encoding run 1 (EMM = 0.159; CI[0.081, 0.236]; t (311.451) = 4.039; p < 0.001), which decreased over encoding runs (EMS = −0.104; CI[−0.141, −0.066]; t (18371.03) = −6.25; p < 0.001) but failed to reach statistical significance (memory × emotion × run, β = −0.088; t (18371.030) =−2.382; p corr = 0.068).

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