Magnetic Resonance Imaging as a Readout of CLN5 Gene Therapy Efficacy in Sheep.

Brain Behav · 2025 · PMC11968780 · PMID 40181626

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a clear trendno p-value reported

A clear trend was observed between age of treatment and volume.

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did not reach statistical significanceno p-value reported

GM volume was slightly higher, and CSF volume was slightly lower compared to untreated CLN5 −/− sheep; however, did not reach statistical significance.

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