Gene expression analysis in circulating tumour cells to determine resistance to CDK4/6 inhibitors plus endocrine therapy in HR + /HER2- metastatic breast cancer patients.

J Transl Med · 2025 · PMC11971781 · PMID 40186268

Europe PMC DOI

hedged sentences

0.0800

closest p · 1.6× alpha

0.0800

boldest claim

The sentences

showed a trendp-value = 0.08so close (0.05 < p ≤ 0.1)

Having metastasis in both visceral and bone locations showed a trend towards a shorter OS compared with having only one location affected ( p-value = 0.08, log-rank test).

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near-significantno p-value reported

Additionally, CDK4 and CDK6 showed a near-significant association (p value: 0.06).

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