Timing of cerebrospinal fluid diversion with ventriculoperitoneal shunt placement in cranioplasty reconstruction: A systematic review and meta-analysis.

Aggregating these studies through meta-analysis demonstrated a trend toward increased risk of complication with this sequence of procedures that did not reach statistical significance [OR 1.89, 95% CI 0.36, 5.62; Figure 4a ].

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In stark contrast to their overall complication rate above, pooled analysis of patients receiving CP -prior-to-shunt showed a trend toward a lower likelihood of complication, though this result also did not achieve statistical significance.

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