Ethnicity-Specific Molecular Alterations in MAPK and JAK/STAT Pathways in Early-Onset Colorectal Cancer.

Cancers (Basel) · 2025 · PMC11988162 · PMID 40227607

Europe PMC DOI

hedged sentences

0.0730

closest p · 1.5× alpha

0.0730

boldest claim

The sentences

did not reach statistical significancep = 0.073so close (0.05 < p ≤ 0.1)

Although the difference in overall survival did not reach statistical significance, the p -value ( p = 0.073) suggests a borderline association.

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showed a trendno p-value reported

In contrast, JAK/STAT pathway alterations in H/L EOCRC patients showed a trend toward worse survival outcomes, though the difference was only borderline significant ( p = 0.073).

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borderline significantno p-value reported

Survival analysis revealed borderline significant differences in H/L EOCRC patients, whereas NHW EOCRC patients with no alterations in the JAK/STAT pathway exhibited significant survival differences.

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highly significantno p-value reported

The highly significant p -value (<0.0001) indicates a strong association between JAK/STAT pathway alterations and poorer survival, highlighting its potential prognostic relevance.

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