SMPD3 as a Potential Biomarker and Therapeutic Target in Hepatocellular Carcinoma.

Int J Genomics · 2025 · PMC11991764 · PMID 40226357

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

0.1940

boldest claim

The sentences

showed a trendp = 0.05actually significant

Patients with Stage T1 tumors showed a trend toward longer survival with high SMPD3 expression level ( p = 0.05), although it was of borderline statistical significance.

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did not reach statistical significancep = 0.194not close (p > 0.1)

In contrast, while positive portal vein invasion had an elevated HR of 1.608 (95% CI: 0.785–3.294), it did not reach statistical significance ( p = 0.194), suggesting that its impact on survival may be less pronounced when other variables are taken into account.

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