Senolytic therapy combining Dasatinib and Quercetin restores the chondrogenic phenotype of human osteoarthritic chondrocytes by the release of pro-anabolic mediators.

Although not all experiments reached statistical significance, a clear trend was found regarding the reduction of SASP factors after senolysis. 3.6 RNA ‐sequencing reveals downregulation of SASP factors and upregulation of chondroanbolic markers and growth factors To further investigate the underlying pathways and potential key factors involved in D + Q‐mediated senolytic and chondrogenic effects, transcriptomic analysis was performed.

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Furthermore, we observed a negative trend in the transcription of YAP1 itself.

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