Integration of scRNA-Seq and Bulk RNA-Seq Identifies Circadian Rhythm Disruption-Related Genes Associated with Prognosis and Drug Resistance in Colorectal Cancer Patients.

Both neuroblastoma and osteosarcoma datasets showed a trend of decreasing CRD scores over time, suggesting that CRD may undergo dynamic changes during tumor progression.

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In the comparative analysis of metabolic pathways between high and low score groups, although gluconeogenesis and glycolysis pathways showed slightly higher enrichment scores in the high score group, these differences did not reach statistical significance.

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