microRNA-218-5p coordinates scaling of excitatory and inhibitory synapses during homeostatic synaptic plasticity.

48 h treatment with Bicuculline (BIC), a GABA-A-R antagonist which was used instead of PTX for technical reasons in these experiments, robustly induced HSD in NC-transfected neurons as evidenced by a highly significant decrease in mEPSC amplitudes compared to the mock-treated condition ( Fig. 2 A – C ).

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miR-218-5p further showed a trend toward upregulation in the soma compartment, but this did not reach statistical significance.

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PTX treatment failed to further decrease spine volume in LNA218 transfected neurons compared to mock treatment but rather exhibited a nonsignificant trend toward an increased size (observed in 7 of 8 replicates, with a 1.07-fold change compared to mock-treated LNA218 condition).

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