Because a highly significant sex by diagnosis interaction indicates that the two sexes respond differently to the disease state, we proceeded to explore this with a sex‐stratified two‐way ANOVA by diagnosis and region.
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In AD men, the highest ratios were also observed in the subiculum, but the difference did not reach statistical significance.
Post hoc comparison of men and women also demonstrated lower TSPO density in AD men relative to women, which was significant in the DG and approached significance in CA1 (Figure 1C ).