Geographic Variation in Epigenetic Responses to Hypoxia in Deer Mice (Peromyscus maniculatus) Distributed Along an Elevational Gradient.

We found that cytosines around the chr14:16866983 DMS (+/− 1 kb) and approaching significance (i.e., p < 0.05; p adj > 0.05) also showed evidence for hypermethylation in hypoxia‐exposed lowland mice (Figure S3A ).

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To assess if DMSs were physically clustered and potentially formed a differentially methylated region (DMR), we highlighted cytosines that were located ± 1 kb of the DMS and approached significance when the region itself displayed methylation signatures in the same direction as the reported DMS.

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