Neurological outcomes and mortality following hyperoxemia in adult patients with acute brain injury: an updated meta-analysis and meta-regression.

Crit Care · 2025 · PMC12020189 · PMID 40270034

Europe PMC DOI

hedged sentences

0.0780

closest p · 1.6× alpha

0.3000

boldest claim

The sentences

did not reach statistical significancep = 0.078so close (0.05 < p ≤ 0.1)

The overall funnel plot showed slight asymmetry though the Egger test did not reach statistical significance (p = 0.078) (Figure S2 in the Supplement).

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showed a trendp = 0.3not close (p > 0.1)

Studies with a lower risk of bias (“good” versus “not good”) showed a trend towards greater effect size (p = 0.3 for neurological outcomes, p = 0.08 for mortality).

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