CK2B Induces CD8<sup>+</sup> T-Cell Exhaustion through HDAC8-Mediated Epigenetic Reprogramming to Limit the Efficacy of Anti-PD-1 Therapy in Non-Small-Cell Lung Cancer.

The high‐expression group showed a trend toward ( P = 0.154) poorer PFS than the low‐expression group, although the difference was not significant (Figure S9B , Supporting Information).

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At the same time, we observed that compared to the Tex‐term‐only adoptive cellular therapy group, the Tex‐term plus CX4945 group had a significantly lower proportion of CD8 + Tex‐term cells, a significant increase in double‐negative T cells, and a trend toward an increased proportion of Tpex cells (although this trend did not reach statistical significance) (Figure S4H,I , Supporting Information).

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