Induction of cardiac fibulin-4 protects against pressure overload-induced cardiac hypertrophy and heart failure.

After 4 days, both beating frequency and dynamic contraction force of the fibulin-4 +/R microtissues showed a trend towards decreasing to levels comparable with the fibulin-4 R/R microtissues (Fig. 2d, e ).

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In line with our previous findings in fibulin-4 R/R mice, in fibulin-4 +/R mice we observed a strong trend towards activation of ERK1/2, which, as a member of the mitogen-activated protein kinase family, is involved in cardiac remodeling and dysfunction 29 , 30 .

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