Location and extent of disease predicts outcome of neurofibromatosis type 1-related pediatric low-grade gliomas.

In patients that had undergone at least one relapse, OPGs also showed a trend toward more severe neurologic deficits over time than BSGs (not shown) and a statistically significant increase in neurologic deficits over time when compared to all non-OPGs ( Figure 1F ).

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OPGs trended toward a shorter time to second progression when compared to the BSG subgroup, but this did not reach statistical significance, likely due to insufficient sample size ( Figure 1D ).

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