Temperature as a Key Modulator: Investigating Phosphorylation Patterns of p.Asn666 <i>PDGFRB</i> Variants and Their Role in Downstream Signaling.

The p.Asn666Ser variant showed a trend to higher PDGFR β phosphorylation at 32°C; however, this was not statistically significant ( Figure 1 ).

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We observed that p.Asn666Tyr, p.Asn666Lys, and p.Asn666His showed further increased total phosphorylation of PDGFR β at 32°C measured by ELISA, while p.Asn666Ser did not reach statistical significance ( Figure 1 ).

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