Multi‑omics analysis identifies different molecular subtypes with unique outcomes in early-stage poorly differentiated lung adenocarcinoma.

In contrast, a trend toward improved prognosis was observed in patients classified as the C2 subtype who received adjuvant chemotherapy, although this difference did not reach statistical significance ( p = 0.301).

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This constrained statistical power may explain why certain clinically apparent trends—particularly regarding differential responses to adjuvant chemotherapy across the three subtypes—failed to reach statistical significance.

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