Use of prescription opioids and other psychotropic drugs during pregnancy and their impact on the mother and developing child: protocol for a cohort study using linked administrative data from Manitoba and British Columbia, Canada.

23 A meta-analysis of five case-control studies showed a trend of poorer neurobehavioural outcomes measured in cognitive, psychomotor and behaviour domains among exposed children, but these differences did not reach statistical significance. 24 A series of small studies of children in Norway demonstrated lower cognitive function and IQ scores and more depressi

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23 A meta-analysis of five case-control studies showed a trend of poorer neurobehavioural outcomes measured in cognitive, psychomotor and behaviour domains among exposed children, but these differences did not reach statistical significance. 24 A series of small studies of children in Norway demonstrated lower cognitive function and IQ scores and more depression, anxiety, attention problems and antisocial behaviours in children exposed to opioids in utero. 25 27 Another showed that prenatal exposure to opioids was associated with an i

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