Oxidative DNA damage promotes vascular ageing associated with changes in extracellular matrix-regulating proteins.

Cardiovasc Res · 2025 · PMC12054627 · PMID 38717632

Europe PMC DOI

hedged sentences

0.0900

closest p · 1.8× alpha

0.0900

boldest claim

The sentences

a negative trendP = 0.09so close (0.05 < p ≤ 0.1)

Fourth, although Ogg1 mRNA expression showed a negative trend with human age, this did not reach statistical significance ( P = 0.09); however, activity of candidate proteins such as OGG1, FOXO3A, and LOX are regulated at post-transcriptional levels, and AC-OGG1 was negatively correlated with stiffness.

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did not reach statistical significanceno p-value reported

22 wk, while changes in PWV did not reach statistical significance ( Figure 2 C–H ).

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