Development of an iPSC-derived immunocompetent skin model for identification of skin sensitizing substances.

J Tissue Eng · 2025 · PMC12056326 · PMID 40336952

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a clear trendno p-value reported

Although treatments with p -phenylenediamine and DNCB did not result in statistically significant increases, a clear trend toward higher IL-18 secretion was evident.

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did not reach statistical significanceno p-value reported

TSLP secretion showed a significant increase in models treated with p -phenylenediamine, with other sensitizers and the positive control displaying a clear upward trend that did not reach statistical significance.

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