Prognostic impact of tumor-infiltrating lymphocytes in HER2+ metastatic breast cancer receiving first-line treatment.

NPJ Breast Cancer · 2025 · PMC12064824 · PMID 40346114

Europe PMC DOI

hedged sentences

0.0800

closest p · 1.6× alpha

0.2520

boldest claim

The sentences

showed a trendp = 0.08so close (0.05 < p ≤ 0.1)

HER2+/HR− tumors showed a trend toward significantly higher TIL levels compared to HR+ tumors (mean 14.3 vs 11.9, p = 0.08).

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did not reach statistical significancep = 0.252not close (p > 0.1)

When considering TILs as a continuous variable (per 10% increments), higher TILs were associated with a better prognosis but did not reach statistical significance (HR = 0.81, 95% CI: 0.56–1.16, p = 0.252) (Supplementary Table 1 ).

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