Perioperative blood loss of sequential administration of hemocoagulase Agkistrodon and Tranexamic acid for primary total knee arthroplasty: a randomized controlled trial.

J Orthop Surg Res · 2025 · PMC12070700 · PMID 40355919

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showed a trendno p-value reported

Our study revealed that sequential administration of HCA and TXA for perioperative hemostasis in TKA showed a trend toward higher blood loss in the HCA and TXA group, although this did not reach statistical significance, and none of patients had postoperative transfusions.

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did not reach statistical significanceno p-value reported

TBL (HCA and TXA, 1025.3 ± 305.3 mL; TXA-only, 892.4 ± 306.4 mL; P = 0.079), IBL (HCA and TXA, 148.3 ± 60.5 mL; TXA-only, 133.3 ± 56.2 mL; P = 0.328), HBL (HCA and TXA, 877.0 ± 294.6 mL; TXA-only, 759.0 ± 282.4 mL; P = 0.122) did not reach statistical significance in two groups.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.