Therapeutic Potential of Local and Systemic Adipose-Derived Mesenchymal Stem Cell Injections in a Rat Model of Experimental Periodontitis: Implications for Cardiac Function.

Int J Mol Sci · 2025 · PMC12071214 · PMID 40362223

Europe PMC DOI

hedged sentences

0.0500

closest p · 1.0× alpha

0.0700

boldest claim

The sentences

did not reach statistical significancep > 0.05actually significant

While systemic AD-MSC delivery achieved a 42.4% reduction in collagen deposition (12.12 ± 0.6%), this improvement did not reach statistical significance versus untreated periodontitis controls ( p > 0.05), revealing clear therapeutic stratification between delivery modalities. 2.6.

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showed a trendp = 0.07so close (0.05 < p ≤ 0.1)

In contrast, the systemic treatment group exhibited significant bone loss compared to controls ( p = 0.032) but showed a trend toward significant ( p = 0.07) partial restoration of bone support.

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