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Dietary Nucleotides Enhance Neurogenesis, Cognitive Capacity, Muscle Function, and Body Composition in Older Adults: A Randomized, Triple-Blind, Controlled Clinical Trial.

Nutrients · 2025 · PMC12073346 · PMID 40362739

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However, these differential effects did not reach statistical significance within the 10-week intervention period, suggesting that a longer duration may be necessary to detect meaningful distinctions between formulations.

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showed a trendno p-value reported
However, the YN group showed a trend toward greater inflammatory modulation, while the NF group exhibited more pronounced neurotrophic benefits and superior functional improvements, as evidenced by its significantly greater reduction in Timed Up and Go Test time, underscoring its potential advantage in enhancing neuromuscular function and mobility.

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a favorable trendno p-value reported
The NF supplement, composed solely of monophosphate nucleotides, exhibited a favorable trend toward greater BDNF levels, potentially due to the role of nucleotides in neurogenesis and neurotrophic support [ 65 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.