Single-nucleus transcriptomics reveals disease- and pathology-specific signatures in α-synucleinopathies.

In fact, most neuronal clusters exhibited a mild trend for increase in iPD, LRRK2-PD and MSA compared with controls, although this only reached nominal significance for few clusters ( Fig. 2C ).

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MSA exhibited only mild changes, which did not reach statistical significance ( Supplementary Table 2 ).

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For a given cell type cluster, we used the nominally significant genes as input and the expressed genes in the cluster as background to minimize trivial enrichment in cell type markers.

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