Pre-existing morbidity pattern in a Danish testicular cancer cohort: insights beyond the testicular dysgenesis syndrome hypothesis.

Also increased was the risk of chromosomal abnormalities (IRR = 12.37, CI: 1.45–105.6), of which Trisomy 21 was dominant (IRR = 4.15, CI: 1.25–13.76), while ‘other sex chromosome abnormalities, male phenotype’, including Klinefelter Syndrome, did not reach statistical significance (IRR = 6.32, CI: 0.95–42.20) ( Fig. 3 ).

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Other studies claiming supporting evidence of an association between TC and low birth weight and preterm birth, however, failed to reach statistical significance ( Coupland et al. , 2004 ; Stephansson et al. , 2011 ).

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