Barely Significant
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The impact of cholinesterase inhibitors on cognitive trajectories in mild cognitive impairment patients based on amyloid beta status.

Alzheimers Dement · 2025 · PMC12079512 · PMID 41568736

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did not reach statistical significancep = 0.11not close (p > 0.1)
showed a trendno p-value reported
Time‐dependent APOE ε4 showed a trend toward increased risk, though this did not reach statistical significance (HR = 1.27, 95% CI: 0.95 to 1.71, p = 0.11) (Table 2 ).

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