Analysis of humoral and cellular immune activation up to 21 months after heterologous and homologous COVID-19 vaccination.

Front Immunol · 2025 · PMC12081374 · PMID 40386778

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did not reach statistical significancep = 0.0563so close (0.05 < p ≤ 0.1)

showed a trendno p-value reported

Further intra-group analysis at 21 months stratified by infection status (N+ = infected, N− = uninfected) showed a trend toward higher IgM−/IgG+ MBCs induction in infected [N+] subjects compared to uninfected [N−] within the ChAd/BNT group, though this difference did not reach statistical significance ( p = 0.0563) ( Supplementary Figure S7A ).

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