Comparing neutrophil-to-lymphocyte ratio (NLR), absolute neutrophil count (ANC) and derived NLR as predictive biomarkers in first-line immunotherapy for non-small cell lung cancer: a retrospective study.

Transl Lung Cancer Res · 2025 · PMC12082228 · PMID 40386737

Europe PMC DOI

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closest p · 1.4× alpha

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boldest claim

The sentences

a statistical trendP=0.07so close (0.05 < p ≤ 0.1)

An increased NLR ratio was also associated with worse OS in PD-L1-positive patients (HR =1.092 with 95% CI: 1.031–1.157; P=0.003), in non-squamous NSCLC (HR =1.096 with 95% CI: 1.032–1.164; P=0.003) with a statistical trend in squamous NSCLC (HR =1.501 with 95% CI: 0.964–2.336; P=0.07).

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a suggestive trendP=0.07so close (0.05 < p ≤ 0.1)

While this trend was not significantly evident for dNLR, there was a suggestive trend (P=0.07) indicating lower efficacy in predicting clinical outcomes with the dNLR variable.

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did not reach statistical significanceno p-value reported

However, subgroup analyses did not reach statistical significance for the ANC levels.

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