Furthermore, FOXP3 + Tregs and EOMES + T‐cells cells were strongly enriched among bone marrow‐resident CD4 + T‐cells (Figure 1C ), but the percentages of EOMES + CD4 + T‐cells in individual donors were highly variable, and the increases failed to reach statistical significance ( p = 0.09).
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The Human Bone Marrow May Offer an IL-15-Dependent Survival Niche for EOMES<sup>+</sup> Tr1-Like Cells.
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CD4 + T‐cells that expressed the transcription factor EOMESODERMIN (EOMES) were enriched in the bone marrow, although this increase did not reach statistical significance (Figure 1C ).