Macrophage sensitivity to bexmarilimab-induced reprogramming is shaped by the tumor microenvironment.

In adjacent tissues, however, only B cells showed a positive correlation with MoMac Clever-1 expression (p=0.026, Padj=0.099), and we observed a negative trend with FOXP3 ( figure 6I , p=0.033, Padj=0.099).

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Untreated responsive tumors (without ex vivo culture) also showed a trend toward expressing less IFN-responsive genes, especially the immunosuppressive enzymes IL4I1 and IDO1 induced by prolonged IFN exposure, but high interpatient variation prevented us from making statistical conclusions based on individual genes ( online supplemental figure S2B ).

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