A reduced ability to discriminate social from non-social touch at the circuit level may underlie social avoidance in autism.

Nat Commun · 2025 · PMC12085590 · PMID 40382316

Europe PMC DOI

hedged sentences

0.0510

closest p · 1.0× alpha

0.0640

boldest claim

The sentences

approached significancep = 0.051so close (0.05 < p ≤ 0.1)

However, we do point out interesting trends that approached significance in Fig. 1d ( p = 0.051), Fig. 3d ( p = 0.055), Fig. 5c ( p = 0.054), and Supplementary Fig. 10c ( p = 0.052).

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did not reach statistical significancep = 0.064so close (0.05 < p ≤ 0.1)

Additionally, we found higher values in WT mice than in Fmr1 KO mice for the two main AFE regressors, orbital area and whisker DLC, although this did not reach statistical significance ( p = 0.064 and 0.111, respectively; non-parametric Mann–Whitney test; n = 5 WT and 4 Fmr1 KO mice; Fig. 7d ).

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