State-of-the-Art Review: Advantages and Disadvantages of Femoral Versus Central Cannulation.

30 Not all published literature supports the superiority of central (and axillary) cannulation in terms of neurologic events; some studies have found no superiority of any cannulation site, 31 and a most recent meta-analysis from the Pittsburgh group in more than 14,000 patients showed a trend toward improved outcomes with central cannulation, which did not reach statistical significance. 32 Vascular and Access Site–Related Complications Arterial cannulation for CPB involves manipulation of large vessels, which bears the risk of vascular complications such as iatrogenic (retrograde) dissection, bleeding, pseudoaneurysms, and formation of hematoma.

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