The human RNASET2 alarmin-like molecule differentially affects prostate cancer cells behavior in both cell autonomous and non-cell autonomous manners.

Our analysis indicated that, across various tumor types, RNASET2 expression was associated with a trend for a reduced risk in PCa, even if this association did not reach statistical significance ( p ≥ 0.05) (Fig. 1 B).

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Additionally, while RNASET2-overexpressing PC-3 cells showed a trend towards increased migration, compared to PC-3 empty-vector transfected cells, regardless of FBS presence (Fig. 3 B), RNASET2-overexpressing and empty-vector transfected 22Rv1 cells displayed similar migration activity (Fig. 3 D).

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