Biomarker discovery in Alzheimer's and neurodegenerative diseases using Nucleic Acid Linked Immuno-Sandwich Assay.

Of the nominally significant proteins (Figure S9 in supporting information), several cytokines and immune‐related proteins (interleukin [IL]‐6, logFC = –0.668, P = 0.001; tumor necrosis factor [TNF], logFC = –0.299, P = 0.017; C‐reactive protein [CRP], logFC = –0.45, P = 0.018; IL‐15, logFC = –0.23, P = 0.027; IL‐9, logFC = 0.54, P = 0.49), amyloid peptides (Aβ38, logFC = –0.45, P = 0.004; Aβ42, logFC = –0.43, P = 0.011) and proteins implicated in synucleinopathies (PARK7, logFC = –0.912, P = 0.027; FABP3, logFC = –0.370, P = 0.036) were downregulated.

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The group comparisons included in this pilot study are not sufficiently powered to draw definitive conclusions regarding the novel biomarkers identified or the proteins that did not reach statistical significance but exhibited change, which were numerous.

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