Pre-Treatment Peripheral Blood Parameters as Prognostic Biomarkers in Cancer Patients Receiving Immune Checkpoint Inhibitors.

Int J Hematol Oncol Stem Cell Res · 2025 · PMC12103826 · PMID 40421401

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closest p · 1.2× alpha

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approached significancep= 0.06so close (0.05 < p ≤ 0.1)

In a multivariate analysis for PFS with adjustment for the three variables that were significant predictors in the univariate analysis (lymphocytes, hemoglobin and platelet counts), no variable retained statistical significance, and only lymphocyte counts approached significance with a risk ratio of 1.47 (95% confidence interval: 0.97-2.23, p= 0.06).

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approaching significanceno p-value reported

Among the tested peripheral blood parameters, lymphocytopenia, defined as a peripheral lymphocyte count lower than 1 x 10 9 /L was the most robust predictor of worse OS in univariate and multivariate analyses and of worse PFS in univariate analysis, approaching significance in multivariate analysis.

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