Can Double-Negative B Cells and Marginal Zone B Cells Have a Potential Impact on the Outcome of Kidney Transplantation?

At T0, both the DN and MZB populations demonstrated a decline in frequency and absolute numbers, those the difference did not reach statistical significance.

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Given the observed trend toward significance in the frequency of MZ B cells, the investigation focused on determining the potential of this population as a predictor of rejection.

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In a subsequent analysis of a larger number of preemptive and non-preemptive recipients, recipients with higher pre-transplant MZB frequencies showed a trend toward an increased rejection rate during the first year after transplantation, albeit not statistically significant [ 24 ].

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