Developing nanobodies as allosteric molecular chaperones of glucocerebrosidase function.

Interestingly, also Nb1, Nb2, Nb8, Nb9, and Nb19 showed a trend toward a positive impact on the enzymatic activity of the GCase (between 1.5 and twofold), albeit not statistically significant, while the others seem to have no effects on the enzyme activity (Fig. 2B ).

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Nb4 also presented a trend toward amelioration of trafficking, even though it did not reach statistical significance.

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