Combining Artificial Intelligence and Human Support in Mental Health: Digital Intervention With Comparable Effectiveness to Human-Delivered Care.

J Med Internet Res · 2025 · PMC12117275 · PMID 40152000

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hedged sentences

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

approached significanceP =.06so close (0.05 < p ≤ 0.1)

This reduction was significantly greater than that observed in the waiting control group ( P <.001, d =0.8; Table 5 ), statistically noninferior to the face-to-face therapy control (mean GAD-7 change –6.0, 95% CI –6.6 to –5.5; noninferiority effect P =.002), and approached significance for noninferiority compared with the typed therapy control (mean GAD-7 change –6.6, 95% CI –7.1 to –6.1; noninferiority effect P =.06).

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approaching significanceP =.06so close (0.05 < p ≤ 0.1)

Similarly, for the ITT sample, the digital program showed superiority to waiting control (d=0.8) and noninferiority to face-to-face CBT ( P =.002), with noninferiority to typed CBT approaching significance ( P =.06).

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