Untargeted metabolomics and transcriptomics joint analysis of the effects of polystyrene nanoplastics on lipid metabolism in the mouse liver.

Lipids Health Dis · 2025 · PMC12121128 · PMID 40442648

Europe PMC DOI

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closest p · 1.0× alpha

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did not reach statistical significanceP > 0.05actually significant

A trend toward increased liver weight and HSI was observed in the NPs group; however, the differences did not reach statistical significance ( P > 0.05) (Fig. 4 E and F).

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an increasing trendno p-value reported

Meanwhile, after NPs exposure, the liver weight and hepatosomatic index (HSI) of mice both exhibited an increasing trend, although there were no significant intergroup differences.

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failed to reach statistical significanceno p-value reported

Notably, NPs exposure induced opposing effects on serum lipid profiles, elevating high-density lipoprotein cholesterol (HDL-C) concentrations while suppressing triglyceride (TG) levels, though intergroup differences failed to reach statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.