Insulin resistance mediates the association between physical activity and mortality in US adults with metabolic syndrome.

Sci Rep · 2025 · PMC12122696 · PMID 40442162

Europe PMC DOI

hedged sentences

0.0580

closest p · 1.2× alpha

0.0580

boldest claim

The sentences

borderline significantP = 0.058so close (0.05 < p ≤ 0.1)

Additionally, HOMA-IR exhibited a borderline significant mediating effect between PA and premature mortality (mediation proportion: 10.1%, P = 0.058) (Fig. 4 ).

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did not reach statistical significanceno p-value reported

In contrast, among women in the HLPA group, the reduction in mortality risk (HR = 0.68, 95% CI: 0.42–1.11) did not reach statistical significance.

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showed a trendno p-value reported

Regarding cancer mortality, while the LLPA and MLPA groups showed a trend toward reduced risk, the results were inconclusive, likely due to small effect sizes leading to confidence intervals that included the null value.

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