SOX9 suppresses colon cancer via inhibiting epithelial-mesenchymal transition and SOX2 induction.

J Clin Invest · 2025 · PMC12126244 · PMID 40179020

Europe PMC DOI

hedged sentences

0.0810

closest p · 1.6× alpha

0.0810

boldest claim

The sentences

near-significantP = 0.081so close (0.05 < p ≤ 0.1)

For DSS, lower SOX9 expression showed a near-significant association (HR = 0.70; 95% CI: 0.47–1.00; P = 0.081) with poorer outcomes, while more lymph node involvement (N2 vs.

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approaching significanceno p-value reported

Moreover, AS organoids also had significantly increased levels of transcription factors known to induce EMT — Snai1 (by 4-fold) and Twist1 (by 48-fold) as well as a trend for Snai2 expression (by 12-fold, approaching significance) — relative to A organoids ( Supplemental Table 1 ).

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